Laryngoscopic View Classification Essay


For many individuals, the advent of modern airway management begins with Miller’s straight-blade laryngoscope [1Miller R. A new laryngoscope. Anesthesiology 1941; 2(3): 317-20.
[] [PMID: 21023368] ], which is itself an improvement over earlier developments [2Bailey B. Laryngoscopy and laryngoscopes--who’s first?: the forefathers/four fathers of laryngology. Laryngoscope 1996; 106(8): 939-43.
[] [PMID: 8699905] ]. The curved laryngoscope blade in common use today, designed to fit into the vallecula and lift the epiglottis anteriorly, was first introduced around 70 years ago [3Macintosh R. A new laryngoscope. Lancet 1943; 1: 205.
[] ]. Since that time, considerable thought has gone into establishing the optimal design and use of laryngoscopes [4McIntyre JW. Laryngoscope design and the difficult adult tracheal intubation. Can J Anaesth 1989; 36(1): 94-8.
[] [PMID: 2644052] -9Pieters BM, Wilbers NE, Huijzer M, Winkens B, van Zundert AA. Comparison of seven videolaryngoscopes with the Macintosh laryngoscope in manikins by experienced and novice personnel. Anaesthesia 2016; 71(5): 556-64.
[] [PMID: 26973253] ].

The advent of technical methods to go beyond traditional line-of-sight laryngoscopic techniques led to a variety of optical and rigid fiberoptic designs (e.g., Bullard, Airtraq) [10Cheyne DR, Doyle P. Advances in laryngoscopy: rigid indirect laryngoscopy. F1000 Med Rep 2010; 2: 61.
[PMID: 21173879] ] and later, electronic devices to facilitate laryngoscopy (videolaryngoscopes). Developments in videolaryngoscopy have been reviewed by numerous authorities [11Van Zundert A, Stessel B, De Ruiter F, Giebelen D, Weber E. Video-assisted laryngoscopy: a useful adjunct in endotracheal intubation. Acta Anaesthesiol Belg 2007; 58(2): 129-31.
[PMID: 17710902] -17Paolini JB, Donati F, Drolet P. Review article: video-laryngoscopy: another tool for difficult intubation or a new paradigm in airway management? Can J Anaesth 2013; 60(2): 184-91.
[] [PMID: 23233395] ].

Descriptions of the early use of the GlideScope videolaryngoscope have been provided by a number of authors [18Agrò F, Barzoi G, Montecchia F. Tracheal intubation using a Macintosh laryngoscope or a GlideScope in 15 patients with cervical spine immobilization. Br J Anaesth 2003; 90(5): 705-6.
[] [PMID: 12697606] -24Rai MR, Dering A, Verghese C. The Glidescope system: a clinical assessment of performance. Anaesthesia 2005; 60(1): 60-4.
[] [PMID: 15601274] ]. Subsequently, an overwhelming number of publications on the design and use of the GlideScope (GS) and other videolaryngoscopes have been published, as noted in some of the above cited reviews. This review aims to update the reader with respect to the art and science of the GlideScope videolaryngoscope, its relation to other airway management products and it application to various clinical scenarios. Out of necessity, we have specifically not reviewed other videolaryngoscope designs except if they are related to the GlideScope in comparative studies.


Healy et al. have provided a taxonomy of videolaryngoscope designs that helps one understand the design of the GS in relation to other videolaryngoscope designs [16Healy DW, Maties O, Hovord D, Kheterpal S. A systematic review of the role of videolaryngoscopy in successful orotracheal intubation. BMC Anesthesiol 2012; 12: 32.
[] [PMID: 23241277] ] (Fig. 1). Fig. 2 and Table 1 illustrates the various members of the GS family of airway products. The reusable GS designs utilize a high-resolution microminiature video camera embedded into a plastic laryngoscope blade. A second design uses a transparent disposable blade that fits over a long thin “video baton”. The blades are angled at 60 degrees up from the horizontal. The main advantage of the version utilizing disposable blades is that the GS can be made available for reuse in a mere few seconds, eliminating the logistical difficulties of disinfection between uses (simply swap out the blade), while the reusable unit requires high-level disinfection between uses, a process that makes the GS otherwise unavailable. (Detailed cleaning instructions are available at the manufacturer's Web site.)

Fig. (1)
A classification of videolaryngoscopic devices provided by Healy et al. (2012). In this system videolaryngoscopes are classified according their shape and form: Left: videolaryngoscopes with an integrated channel (to guide placement of the endotracheal tube). Middle: videolaryngoscopes taking the form of a videostylet (with the endotracheal tube placed around the device). Right: videolaryngoscopes with a rigid blade (without a channel, the endotracheal tube requiring some kind of independent stylet to guide placement).

Fig. (2)
Some members of the GlideScope family. Top: The GVL family of reusable GlideScopes. Technical specifications are available in (Table 2). Middle: The GlideScope Direct, designed to assist in the teaching of direct laryngoscopy. It is a reusable video-enabled Macintosh laryngoscope designed for the specific purpose of teaching direct laryngoscopy. In contrast to other devices in the GlideScope product line, such as the GVL, Cobalt, and Ranger, which have a view axis of around 290°, the GlideScope Direct is a Macintosh 3.5 blade with a traditional view axis of 90° along the operator’s direct line of sight. Bottom: The GlideScope Titanium is available in two models. The first is a low-profile hyper-angulated blade, available in two sizes, while the second uses a more traditional Macintosh blade, also available in two sizes. Both designs offer full-color imaging, with LED illumination as well as anti-fog technology. Four models of single-use video laryngoscopes are also available. Images courtesy of Verathon Medical, manufacturer of the GlideScope. (

From: Healy DW, Maties O, Hovord D, Kheterpal S. A systematic review of the role of videolaryngoscopy in successful orotracheal intubation. BMC Anesthesiol. 2012 Dec 14;12:32. doi: 10.1186/1471-2253-12-32. PubMed PMID: 23241277; PubMed Central PMCID: PMC3562270.

Copyright ©2012 Healy et al.; licensee BioMed Central Ltd. From an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Table 1
Some technical specifications for the GVL members of the GS family (see Fig. 2 - top).

Two later GS designs consist of a reusable unit (AVL Reusable) that is available in 4 sizes (GVL 2,3,4,5) as well as a version featuring disposable blades (AVL Single Use) that is available in 6 sizes (AVL 0, 1, 2, 2.5, 3, 4) in association with two sizes of video batons. Both units feature an HDMI output for optional connection to external monitors, a built-in educational tutorial to familiarize users with the unit, and a USB port where recorded videos can be saved onto a flash drive.

The latest GS products are made from titanium and are available in two models. The first is a low-profile hyper-angulated blade, available in two sizes, while the second uses a more traditional Macintosh blade, also available in two sizes. Both designs offer full-color imaging, with LED illumination as well as anti-fog technology. Four models of single-use video laryngoscopes are also available.


The curved blade shape of the GlideScope is simple to place, and users quickly feel comfortable inserting the device and distracting the tongue and jaw, in a manner similar to direct laryngoscopy. Users should use the GS like a regular Macintosh laryngoscope with the exception that they should intubate with the head in the neutral position and that they should watch the LCD display monitor instead of looking directly only after the ETT is placed into the oropharynx (see discussion on complications). Note that the image provided by the GlideScope Fig. (3) is looking upward toward the larynx from within the hypopharynx, and consequently is not dependent on patient head-neck position. A neutral position (face plane parallel to the ceiling) allows more oropharyngeal space compared to atlanto-occipital extension, which narrows the hypopharyngeal space.

Fig. (3)
Views of an endotracheal tube passing into the glottis. (From Dr. Doyle’s Case 112 taken using the original monochrome GlideScope).

As a rule, few difficulties are encountered in obtaining an adequate view in the few seconds it takes most users to learn to manipulate the GS. In some cases, the view is improved with posterior displacement of the trachea, but in most cases, this maneuver is not helpful (see discussion on usage tips). The fact that several individuals can simultaneously witness the intubation on the LCD display is of enormous teaching value and can be clinically valuable in difficult cases where significant pathology is found. The GS works fairly well in the presence of blood and secretions (a consequence of the protected camera position on the blade) but the presence of vomitus, hemoptysis or hematemesis can impair the view; in such cases, it is wise to suction the oropharynx thoroughly prior to insertion.

Many users find that the principal limitation in using the GS is not in getting a good view of the glottis, but rather in manipulating the endotracheal tube (ETT) through the vocal cords. Using an ordinary ETT without a stylet results in a floppy ETT that is very hard to direct through the cords, and successful placement almost always requires some form of stylet, such as a Mallinckrodt Satin-Slip® Intubating Stylet, or the GlideRite Stylet Fig. (4) in order to avoid the ETT from ending up in an excessively posterior position.

Fig. (4)
ETT bent at a 90-degree angle (“hockey stick”) for use with the GlideScope.

Studies showing the GS to be easier to use than DL are numerous. For example, Healy et al. [16Healy DW, Maties O, Hovord D, Kheterpal S. A systematic review of the role of videolaryngoscopy in successful orotracheal intubation. BMC Anesthesiol 2012; 12: 32.
[] [PMID: 23241277] ] compared the Glidescope, CMAC, and Storz DCI with the Macintosh laryngoscope during simulated manikin difficult laryngoscopy; all three of the methods of video laryngoscopy studied were found to be superior to the Macintosh laryngoscope Fig. (5). This issue is discussed in more detail in a later section.

Fig. (5)
Results of a manikin-based difficult airway study by Healy et al. (2012) showing that the three vidolaryngoscopes studied provided better Cormack-Lehane views than the Macintosh laryngoscope.

From: Healy DW, Picton P, Morris M, Turner C. Comparison of the Glidescope, CMAC, storz DCI with the Macintosh laryngoscope during simulated difficult laryngoscopy: a manikin study. BMC Anesthesiol. 2012 Jun 21;12:11. doi: 10.1186/1471-2253-12-11. PubMed PMID: 22720884; PubMed Central PMCID: PMC3519500.

Copyright ©2012 Healy et al.; licensee BioMed Central Ltd. From an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Experience shows that the principal limitation in using the GS is not in getting a good view of the glottis, but rather in manipulating the tracheal tube through the vocal cords. Successful tracheal tube placement is usually best achieved by using a stylet formed in the shape of a ‘hockey stick’ (with a 90° bend) to help ensure that the tube is directed sufficiently anteriorly to enter the glottis Fig. (4). Once the tube enters the glottis, it is can also be helpful to withdraw the stylet by about 3 cm, followed by advancing the tube slightly, so as to avoid it hitting against the tracheal wall [23Doyle DJ. The GlideScope video laryngoscope. Anaesthesia 2005; 60(4): 414-5.
[] [PMID: 15766351] ].

Walls et al. [25Walls RM, Samuels-Kalow M, Perkins A. A new maneuver for endotracheal tube insertion during difficult GlideScope intubation. J Emerg Med 2010; 39(1): 86-8.
[] [PMID: 20097502] ] described a patient where extreme difficulty in using the GlideScope occurred despite a CL grade 1 laryngoscopic view because “the trachea formed a steep posterior angle with the laryngeal/glottic axis” with the ETT tip consequently becoming stuck against the anterior tracheal wall. Successful intubation was ultimately achieved by rotating the ETT 180 degrees, thereby redirecting the ETT posteriorly.

Corda et al. [26Corda DM, Riutort KT, Leone AJ, Qureshi MK, Heckman MG, Brull SJ. Effect of jaw thrust and cricoid pressure maneuvers on glottic visualization during GlideScope videolaryngoscopy. J Anesth 2012; 26(3): 362-8.
[] [PMID: 22410965] ] found that a jaw thrust maneuver was often helpful in improving the glottic view when the GlideScope is used, but that no significant improvement was noted with cricoid pressure. They “recommend the use of jaw thrust as a first-line maneuver to aid in glottic visualization and tracheal intubation during GlideScope videolaryngoscopy.”

Table 2 provides additional tips. Other potentially helpful suggestions have been offered by other GlideScope experts [27Heitz JW, Mastrando D. The use of a gum elastic bougie in combination with a videolaryngoscope. J Clin Anesth 2005; 17(5): 408-9.
[] [PMID: 16102701] -39Bacon ER, Phelan MP, Doyle DJ. Tips and troubleshooting for use of the glideScope video laryngoscope for emergency endotracheal intubation. Am J Emerg Med 2015; 33(9): 1273-7.
[] [PMID: 26008581] ].

Table 2
Some expert tips for successful glideScope use.


The Endotrol-tracheal tube has a control that allows the tube tip to be positioned to a more anterior position. Imagining that this feature might be helpful for intubation using the GS, Cattano et al. [40Cattano D, Artime C, Maddukuri V, et al. Endotrol-tracheal tube assisted endotracheal intubation during video laryngoscopy. Intern Emerg Med 2012; 7(1): 59-63.
[] [PMID: 21948313] ] conducted a study in which two of the study arms compared the GS used in conjunction with the Endotrol ETT (but employing no stylet) against the GS using a GlideRite-styletted standard ETT. The authors concluded that “the Endotrol ETT, as compared to a standard ETT with a non-malleable stylet, is associated with longer intubation times and a subjective increase in difficulty of use.”


While the GS generally provides a superior glottic view compared to DL, predictive features specific to difficult GS intubation have not been identified to the extent that they have for DL. Tremblay et al. [41Tremblay MH, Williams S, Robitaille A, Drolet P. Poor visualization during direct laryngoscopy and high upper lip bite test score are predictors of difficult intubation with the GlideScope videolaryngoscope. Anesth Analg 2008; 106(5): 1495-500. [table of contents.].
[] [PMID: 18420866] ] recorded demographic and morphometric factors for 400 patients undergoing tracheal intubation. After induction, DL was performed to determine the Cormack / Lehane grade of glottic visualization [42Cormack RS, Lehane J. Difficult tracheal intubation in obstetrics. Anaesthesia 1984; 39(11): 1105-11.
[] [PMID: 6507827] , 43Kharbouch H, Peel W. Updating the Cormack and Lehane classification. Anaesthesia 2007; 62(7): 754.
[] [PMID: 17567370] ], followed by intubation using the GS. After their data analysis, the only predictors of difficulty with GS intubation (e.g., multiple attempts) turned out to be high Cormack / Lehane grades during direct laryngoscopy, a high upper lip bite test score [44Khan ZH, Kashfi A, Ebrahimkhani E. A comparison of the upper lip bite test (a simple new technique) with modified Mallampati classification in predicting difficulty in endotracheal intubation: a prospective blinded study. Anesth Analg 2003; 96(2): 595-9. [table of contents.].
[PMID: 12538218] ] and a short sternothyroid distance. Of these, only the last two, of course, can be assessed at the bedside.

Adnet's intubation difficulty scale (IDS) [45Adnet F, Borron SW, Racine SX, et al. The intubation difficulty scale (IDS): proposal and evaluation of a new score characterizing the complexity of endotracheal intubation. Anesthesiology 1997; 87(6): 1290-7.
[] [PMID: 9416711] ] has been used extensively as a metric to define difficult intubation and to compare methods of intubation. For example, Yousef et al. [46Yousef GT, Abdalgalil DA, Ibrahim TH. Orotracheal intubation of morbidly obese patients, comparison of GlideScope(®) video laryngoscope and the LMA CTrach™ with direct laryngoscopy. Anesth Essays Res 2012; 6(2): 174-9.
[] [PMID: 25885612] ] used the IDS to compare the GlideScope, the LMA CTrach™ and direct laryngoscopy in a population of 90 obese patients. The authors found that “easy, moderately difficult, and difficult tracheal intubation as defined by the intubation difficulty score (0, 1-5, and >5) were met in 12, 11, and 7 patients of the DL group, respectively, while, tracheal intubation was easy in (29, 28 patients) and moderately difficult in only (1, 2 patients) in the GVL and CT groups, respectively. The authors concluded that “the GlideScope videolaryngoscope improved intubation time for tracheal intubation with less upper airway morbidity compared with the LMACTrach and Macintosh direct laryngoscope.”

However, a study by McElwain et al. [47McElwain J, Simpkin A, Newell J, Laffey JG. Determination of the utility of the Intubation Difficulty Scale for use with indirect laryngoscopes. Anaesthesia 2011; 66(12): 1127-33.
[] [PMID: 21967144] ] found that the correlation between the IDS score and both user rated difficulty and the time needed for tracheal intubation was significantly stronger for the Macintosh laryngoscope than for the indirect laryngoscopes studied (GlideScope, Pentax AWS, Airtraq). These findings led the authors to conclude that the IDS “performs less well with indirect laryngoscopes than with the Macintosh laryngoscope” and that clinicians should use “caution with the use of this score with indirect laryngoscopes.”


Because forces applied to airway soft tissues by direct laryngoscopy may cause injury as well as an endocrine stress response, a number of investigators have studied the forces applied during laryngoscopy and intubation.

Hirabayashi et al. [48Hirabayashi Y, Fujita A, Seo N, Sugimoto H. Distortion of anterior airway anatomy during laryngoscopy with the GlideScope videolaryngoscope. J Anesth 2010; 24(3): 366-72.
[] [PMID: 20364439] ] considered the possibility that a reduction in forces applied during GS laryngoscopy might result in reduced anterior airway anatomy distortion, providing a possible explanation of the perception that nasotracheal intubation with the GS is easier than when DL is used. To study this hypothesis that authors studied 20 patients in a protocol where each patient underwent laryngoscopy using both the GS and DL with Macintosh blade. During each laryngoscopy, a radiograph was taken when the best view of the larynx was obtained, and these radiographs were then studied for anterior airway distortion and cervical spine movement. The distance between the epiglottis and the posterior pharyngeal wall during GS use was found to be reduced by 21% as compared to Macintosh laryngoscopy. The authors concluded that “both anterior airway distortion and cervical spine movement during laryngeal visualization” were reduced for with use of the GS.

Russell et al. [49Russell T, Khan S, Elman J, Katznelson R, Cooper RM. Measurement of forces applied during Macintosh direct laryngoscopy compared with GlideScope® videolaryngoscopy. Anaesthesia 2012; 67(6): 626-31.
[] [PMID: 22352799] ] compared the forces used with the Macintosh laryngoscope vs. the GlideScope in 24 adult patients using three FlexiForce pressure sensors attached along the concave surface of each blade. Compared with the Macintosh laryngoscope, the authors found lower median peak force (9 N vs 20 N), average force (5 N vs 11 N) and impulse force (98 N vs 150 N) with the GlideScope. Methodological comments on this study have been provided by Pieters et al. [50Pieters B, van Zundert A, Lee R. Measurement of forces during direct laryngoscopy and videolaryngoscopy. Anaesthesia 2012; 67(10): 1182-3.
[] [PMID: 22950408] ]. A similar study using manikins has been published by the same team [51Lee C, Russell T, Firat M, Cooper RM. Forces generated by Macintosh and GlideScope® laryngoscopes in four airway-training manikins. Anaesthesia 2013; 68(5): 492-6.
[] [PMID: 23573844] ]. Carassiti et al. [52Carassiti M, Biselli V, Cecchini S, et al. Force and pressure distribution using Macintosh and GlideScope laryngoscopes in normal airway: an in vivo study. Minerva Anestesiol 2013; 79(5): 515-24.
[PMID: 23419341] ] similarly compared the Macintosh laryngoscope vs. the GlideScope in a study of 30 adult patients using film pressure transducers. They found that the force applied using the GlideScope was much lower than with the Macintosh (8 N vs. 40 N on average). They also noted that when using the Macintosh laryngoscope, forces were concentrated mostly on the tip, whereas the GlideScope “distributes the forces more homogeneously to the tissue”, reducing the potential for injury. An earlier manikin study of similar design was published by Carassiti et al. [53Carassiti M, Zanzonico R, Cecchini S, Silvestri S, Cataldo R, Agrò FE. Force and pressure distribution using Macintosh and GlideScope laryngoscopes in normal and difficult airways: a manikin study. Br J Anaesth 2012; 108(1): 146-51.
[] [PMID: 21965048] ]. Methodological comments on this last study have been provided by Fiadjoe and Stricker [54Fiadjoe JE, Stricker P. Force and pressure distribution using Macintosh and GlideScope laryngoscopes. Br J Anaesth 2012; 108(4): 698. [author reply].
[] [PMID: 22419625] ].


Mask ventilation as well as intubation can be difficult in morbidly obese patients. These patients are also at increased risk of hypoxemia during tracheal intubation [55Kristensen MS. Airway management and morbid obesity. Eur J Anaesthesiol 2010; 27(11): 923-7.
[] [PMID: 20689440] -57Murphy C, Wong DT. Airway management and oxygenation in obese patients. Can J Anaesth 2013; 60(9): 929-45.
[] [PMID: 23836064] ]. Consequently, a number of studies have examined whether the GlideScope might be helpful in such cases.[REMOVED HYPERLINK FIELD]

Andersen et al. [58Andersen LH, Rovsing L, Olsen KS. GlideScope videolaryngoscope vs. Macintosh direct laryngoscope for intubation of morbidly obese patients: a randomized trial. Acta Anaesthesiol Scand 2011; 55(9): 1090-7.
[] [PMID: 22092206] ] compared GS intubation with the Macintosh direct laryngoscope (DL) in a group of 100 consecutive morbidly obese patients. The authors found that “laryngoscopic views were better in group GS with Cormack-Lehane grades 1/2/3/4 distributed as 35/13/2/0 vs. 23/13/10/4 in group DL” and also found that better IDS scores with use of the GS. However, intubation times were longer in the GS than in the DL group (average of 48 s vs 32 s), although the authors noted that that the “increased intubation time was of no clinical consequence as no patients became hypoxemic.”

A study by Ydemann et al. [59Ydemann M, Rovsing L, Lindekaer AL, Olsen KS. Intubation of the morbidly obese patient: GlideScope® vs. Fastrach™. Acta Anaesthesiol Scand 2012; 56(6): 755-61.
[] [PMID: 22524487] ] compared the GS with the Fastrach (FT) in intubating 100 obese patients. Average GS intubation time was 49 s, with 61 s using the FT, a difference that was not statistically significant. The authors experienced one esophageal intubation using the GS and six when using the FT. Although the authors wrote that the GS and the FT should be “considered to be equally good when intubating morbidly obese patients” the possibility that the study was underpowered to detect any differences between the two techniques should also be considered.

Motivated by concerns about delayed gastric emptying in obese patients, a study by Gupta and Rusin [60Gupta D, Rusin K. Videolaryngoscopic endotracheal intubation (GlideScope) of morbidly obese patients in semi-erect position: a comparison with rapid sequence induction in supine position. Middle East J Anaesthesiol 2012; 21(6): 843-50.
[PMID: 23634566] ] compared rapid-sequence GS intubation in patients induced in the semi-erect position with rapid-sequence GS intubation in the standard supine position. Although “no differences were observed in the intubation parameters or patient safety” desaturation episodes occurred 50% less frequently in the semi-erect group, a finding that did not reach statistical significance.

A study of 150 obese patients by Maassen et al. [61Maassen R, Lee R, Hermans B, Marcus M, van Zundert A. A comparison of three videolaryngoscopes: the Macintosh laryngoscope blade reduces, but does not replace, routine stylet use for intubation in morbidly obese patients. Anesth Analg 2009; 109(5): 1560-5.
[] [PMID: 19713258] ] compared the GlideScope Ranger, Storz V-Mac, and McGrath Series 5 videolaryngoscopes against DL in a cross-over study design. All 3 videolaryngoscopes provided an equal or better view of the glottis as compared to DL. The authors found that the number of attempts necessary to intubate the trachea differed significantly among the devices (average 2.6 attempts for the GS, 1.4 for the Storz, and 2.9 for the McGrath). The average intubation times were 33 s for the GS, 17 s for the Storz, and 41 s for the McGrath VLS. The authors concluded that that Storz V-Mac “had a better overall satisfaction score (and) intubation time” and required a “reduced number of intubation attempts” compared to the other devices tested. One possible criticism of this study was the use of a “very stringent” definition of an intubation attempt, as “each approach of the ETT to the glottic entrance, even without complete withdrawal of the ETT out of the mouth” counted as an attempt. A more serious criticism is that a rigid stylet was employed only “if intubation was not feasible after 2 intubation attempts” despite that fact that routine use of a stylet is recommended by the manufacturers of both the GS and the McGrath devices.

A study by Abdelmalak et al. [62Abdelmalak BB, Bernstein E, Egan C, et al. GlideScope® vs flexible fibreoptic scope for elective intubation in obese patients. Anaesthesia 2011; 66(7): 550-5.
[] [PMID: 21564041] ] compared GS intubation with flexible fibreoptic intubation in 75 obese patients randomly assigned to one of these two intubation methods following the induction of general anesthesia. Although it was hypothesized that tracheal intubation with the GlideScope would be advantageous compared with flexible fibreoptic intubation, no significant differences were found for the time needed to intubate, the difficulty of intubation, the success rate for the first attempt, the number of attempts, the incidence of hypoxemia, the amount of post-intubation bleeding and the incidence of sore throat. While the authors concluded that “for experienced users, the time required to intubate the trachea in anaesthetised obese patients is similar with the GlideScope and a flexible bronchoscope” the much steeper learning curve associated with use of flexible fibreoptic intubation as compared to intubation using the GS suggests that these findings likely apply only to clinicians very experienced with flexible fibreoptic intubation.

Finally, Yumul et al. [63Yumul R, Elvir-Lazo OL, White PF, et al. Comparison of three video laryngoscopy devices to direct laryngoscopy for intubating obese patients: a randomized controlled trial. J Clin Anesth 2016; 31: 71-7.
[] [PMID: 27185681] ] compared three different VL devices (Video-Mac, GlideScope, and McGrath) against DL in obese patients undergoing bariatric surgery and found that all three VL devices studied provided improved glottic views compared to DL (p < 0.05).


In recent years the GlideScope has taken on a special role in managing airway emergencies outside of the Operating Room, such as in the emergency department, ICU or in the prehospital setting. One particularly interesting issue concern the question of whether videolaryngoscopy should be the first choice for tracheal intubation in managing emergency airways in such settings.

Sakles et al. [64Sakles JC, Mosier J, Patanwala AE, Dicken J. Learning curves for direct laryngoscopy and GlideScope® video laryngoscopy in an emergency medicine residency. West J Emerg Med 2014; 15(7): 930-7.
[ 2014.9.23691] [PMID: 25493156] ] compared resident performance for direct laryngoscopy versus the GlideScope over the course of emergency medicine residency training and found that while there was no significant improvement over time in first pass success with direct laryngoscopy, there was “substantial improvement” with use of the GlideScope Fig. (6). In another study by Sakles et al. [65Sakles JC, Javedani PP, Chase E, Garst-Orozco J, Guillen-Rodriguez JM, Stolz U. The use of a video laryngoscope by emergency medicine residents is associated with a reduction in esophageal intubations in the emergency department. Acad Emerg Med 2015; 22(6): 700-7.
[] [PMID: 25996773] ] the authors compared the incidence of esophageal intubation when emergency medicine residents used direct laryngoscopy versus video laryngoscopy for emergency department intubation. In this study the authors concluded that use of video laryngoscopy resulted in “significantly fewer” esophageal intubations in this setting and recommended that emergency medicine residency training programs should consider using video laryngoscopy for all intubations, a position they advocate especially strongly for patients suspected of having a difficult airway [66Sakles JC, Patanwala AE, Mosier JM, Dicken JM. Comparison of video laryngoscopy to direct laryngoscopy for intubation of patients with difficult airway characteristics in the emergency department. Intern Emerg Med 2014; 9(1): 93-8.
[] [PMID: 24002788] ].

Fig. (6)
Results of a study by Sakles et al. (2014). The authors concluded that over the course of residency training in emergency medicine there was no significant improvement in resident first pass success rates when using direct laryngoscopy (DL), but substantial improvement when the GlideScope (GVL) was used for intubation. PGY = post-graduate year of training.

From: Sakles JC, Mosier J, Patanwala AE, Dicken J. Learning curves for direct laryngoscopy and GlideScope® video laryngoscopy in an emergency medicine residency. West J Emerg Med. 2014 Nov;15(7):930-7. doi: 10.5811/westjem.2014.9.23691. Epub 2014 Oct 29. PubMed PMID: 25493156; PubMed Central PMCID: PMC4251257.

Copyright ©2014 Sakles et al. From an Open Access article distributed under the terms of the Creative Commons Non-Commercial Attribution License, which permits its use in any digital medium, provided the original work is properly cited and not altered.

It also appears that the specific type of videolaryngoscope used may be relatively unimportant in emergency department intubation success. Mosier et al. [67Mosier J, Chiu S, Patanwala AE, Sakles JC. A comparison of the GlideScope video laryngoscope to the C-MAC video laryngoscope for intubation in the emergency department. Ann Emerg Med 2013; 61(4): 414-420.e1.
[] [PMID: 23374414] ] reviewed 463 intubations (230 with the GlideScope and 233 with the Storz C-MAC) and found that both yielded similar success rates.

The GlideScope experience in the ICU setting is somewhat similar. Ural et al. [68Ural K, Subaiya C, Taylor C, Ramadhyani U, Scuderi-Porter H, Nossaman BD. Analysis of orotracheal intubation techniques in the intensive care unit. Crit Care Resusc 2011; 13(2): 89-96.
[PMID: 21627576] ] compared intubation before and after acquisition of a GlideScope dedicated to ICU use and found that it did not lead to an “immediate reduction in attempts at orotracheal intubation” or to a reduction in complication rates. By contrast, Kory at al [69Kory P, Guevarra K, Mathew JP, Hegde A, Mayo PH. The impact of video laryngoscopy use during urgent endotracheal intubation in the critically ill. Anesth Analg 2013; 117(1): 144-9.
[] [PMID: 23687228] ]. studied 138 urgent ICU endotracheal intubations carried out by pulmonary and critical care medicine fellows, and found that use of videolaryngoscopy “improved intubation success and decreased complications” compared to direct laryngoscopy. The authors suggested that videolaryngoscopy should be used “when urgent intubations are performed by less experienced operators.”

In a similar ICU study by Silverberg et al. [70Silverberg MJ, Li N, Acquah SO, Kory PD. Comparison of video laryngoscopy versus direct laryngoscopy during urgent endotracheal intubation: a randomized controlled trial. Crit Care Med 2015; 43(3): 636-41.
[] [PMID: 25479112] ] involving pulmonary and critical care medicine fellows, patients urgently in need of intubation were randomized to use of the GlideScope video laryngoscopy or to direct laryngoscopy. Success on the first attempt was achieved in 74% of the GlideScope patients group compared with only 40% amongst the direct laryngoscopy patients.

In the prehospital arena, a number of studies have demonstrated the value of videolaryngoscopy. Bjoernsen and Lindsay [71Bjoernsen LP, Lindsay B. Video laryngoscopy in the prehospital setting. Prehosp Disaster Med. In: 2009; 24: pp. (3)265-70.
[PMID: 19618365] ] opined that while “direct laryngoscopy always should be retained as a primary skill …. the video laryngoscope has the potential to be a good primary choice for the patient with potential cervical spine injuries or limited jaw or spine mobility, and in the difficult-to-access patient.” Struck et al. [72Struck MF, Wittrock M, Nowak A. Prehospital Glidescope video laryngoscopy for difficult airway management in a helicopter rescue program with anaesthetists. Eur J Emerg Med 2011; 18(5): 282-4.
[] [PMID: 21430543] ] conducted a retrospective observational study of their helicopter rescue program and concluded that the GlideScope “may be a valuable support instrument in the prehospital management of difficult airways in emergency patients.”

However, not all prehospital studies of the GlideScope have been favorable. In a study by Trimmel et al. [73Trimmel H, Kreutziger J, Fitzka R, et al. Use of the GlideScope Ranger video laryngoscope for emergency intubation in the prehospital setting: A randomized control trial. Crit Care Med 2016; 44(7): e470-6.
[] [PMID: 27002277] ], prehospital GlideScope use was associated with impaired visualization of the monitor because of ambient light, thus resulting in a lower intubation success rate when compared with direct laryngoscopy (61.9% versus 96.2%.)


The GlideScope can also be used in neonates and pediatric patients. Trevisanuto et al. [74Trevisanuto D, Fornaro E, Verghese C. The GlideScope video laryngoscope: initial experience in five neonates. Can J Anaesth 2006; 53(4): 423-4.
[] [PMID: 16575049] ] described their initial experience with GS use in five neonates and outlined the difficulties encountered. Kim et al. [75Kim JT, Na HS, Bae JY, et al. GlideScope video laryngoscope: a randomized clinical trial in 203 paediatric patients. Br J Anaesth 2008; 101(4): 531-4.
[] [PMID: 18689807] ] compared the use of the GlideScope with direct laryngoscopy in 203 children. The view of the glottis was scored (Cormack and Lehane (C&L) grade) with and without BURP (backward, upward and right-sided pressure) [76Hirabayashi Y, Otsuka Y. The BURP manoeuvre for better glottic view using the paediatric GlideScope. Anaesthesia 2010; 65(8): 862-3.
[] [PMID: 20649927] ] in both instances. The GlideScope improved the view without BURP in the patients with C&L grade 2 (16/26) and with C&L grades 3 and 4 (7/11). The view with BURP was also improved by the GlideScope in C&L grade 2 (4/9) and with C&L grades 3 and 4 (4/5). The average time for intubation was 36.0 s in the GS group and 23.8 s in the DL group. The authors concluded that “in children, the GlideScope provided a laryngoscopic view equal to or better than that of direct laryngoscopy but required a longer time for intubation.”

Lee et al. [77Lee JH, Park YH, Byon HJ, et al. A comparative trial of the GlideScope(R) video laryngoscope to direct laryngoscope in children with difficult direct laryngoscopy and an evaluation of the effect of blade size. Anesth Analg 2013; 117(1): 176-81.
[] [PMID: 23687227] ] evaluated the usefulness of the GS for improving the laryngoscopic view in 23 pediatric patients whose Cormack and Lehane grade under direct laryngoscopy was 3 or 4 and concluded that a Glidescope one size smaller than the usual blade based on weight “significantly improved the laryngoscopic view” when compared with DL or with the GS blade based on weight.

Finally, Vadi et al. [78Vadi MG, Roddy KJ, Ghazal EA, Um M, Neiheisel AJ, Applegate RL 2nd. Comparison of the GlideScope cobalt and storz DCI video laryngoscopes in children younger than 2 years of age during manual in-line stabilization: A randomized trainee evaluation study. Pediatr Emerg Care 2016.
[PMID: 26785097] ] compared trainee intubation times obtained using the GlideScope Cobalt VL, the Storz DCI VL and DL in young children with immobilized cervical spines and concluded that VL “may enhance best Cormack-Lehane glottic view during manual in-line cervical spine immobilization, but additional technical skills are needed to successfully complete tracheal intubation” and that “obtaining a grade 1 Cormack-Lehane glottic view was less likely” with DL.


A number of investigators have studied the question as to the best airway management technique in the patient with suspected cervical spine injury, since in patients with possible cervical spine injury movement head and neck should be minimized [79Siddiqui AK. Airway management for cervical spine injury. Saudi Med J 2009; 30(9): 1133-7.
[PMID: 19750256] , 80Jung JY. Airway management of patients with traumatic brain injury/C-spine injury. Korean J Anesthesiol 2015; 68(3): 213-9.
[] [PMID: 26045922] ].

Turkstra et al. [81Turkstra TP, Craen RA, Pelz DM, Gelb AW. Cervical spine motion: a fluoroscopic comparison during intubation with lighted stylet, GlideScope, and Macintosh laryngoscope. Anesth Analg 2005; 101(3): 910-5.
[] [PMID: 16116013] ] used fluoroscopy to study 36 normal adult patients immobilized with in-line stabilization in a crossover trial of either Trachlight (Intubating Lighted Stylet) or GlideScope intubation to DL. While cervical spine motion using the GS was reduced 50% as compared to DL at the C2-5 segment, no difference was found at the other segments studied. As with other studies, GS laryngoscopy took significantly longer than with DL. The authors found that the best results were obtained using a Trachlight. (More information on Trachlight intubation is available in a comprehensive review by Agro et al. [82Agrò F, Hung OR, Cataldo R, Carassiti M, Gherardi S. Lightwand intubation using the Trachlight: a brief review of current knowledge. Can J Anaesth 2001; 48(6): 592-9.
[] [PMID: 11444456] ]).

Robitaille et al. [83Robitaille A, Williams SR, Tremblay MH, Guilbert F, Thériault M, Drolet P. Cervical spine motion during tracheal intubation with manual in-line stabilization: direct laryngoscopy versus GlideScope videolaryngoscopy. Anesth Analg 2008; 106(3): 935-41.
[] [PMID: 18292443] ] similarly compared cervical spine motion during GS vs DL intubation in 20 patients using continuous fluoroscopy. Manual in-line stabilization of the head was performed. Although no significant difference in average segmental spine movement was found at any segmental level, glottic visualization was “significantly better” with GS use.

Wong et al. [84Wong DM, Prabhu A, Chakraborty S, Tan G, Massicotte EM, Cooper R. Cervical spine motion during flexible bronchoscopy compared with the Lo-Pro GlideScope. Br J Anaesth 2009; 102(3): 424-30.
[] [PMID: 19193652] ] studied cervical spine motion during flexible bronchoscopy as compared with the GS when no cervical immobilization was used, hypothesizing that the GS would not cause significantly greater cervical spine movement than fibreoptic bronchoscopy. To study this matter, 28 adults without cervical disease requiring intubation for radiographic procedures were randomized to either the GS or the flexible bronchoscope (FB), with continuous fluoroscopy used to assess cervical spine movement during intubation. Cervical spine movement was compared both during laryngoscopy and with tongue pull and jaw thrust maneuvers. The authors found that use of the GS during intubation under general anesthesia resulted in greater cervical movement than FB, and that the jaw thrust maneuver, often used to facilitate FB, also resulted in cervical spine movement.

Kill et al. [85Kill C, Risse J, Wallot P, Seidl P, Steinfeldt T, Wulf H. Videolaryngoscopy with glidescope reduces cervical spine movement in patients with unsecured cervical spine. J Emerg Med 2013; 44(4): 750-6.
[] [PMID: 23351572] ] studied cervical spine movement in patients with an unsecured cervical spine, comparing conventional DL with use of the GS in 60 anesthetized patients. Using video motion analysis taken with a lateral view, the maximum extension angle was measured with reference to standardized anatomical points. The authors found that Intubation by physicians with some experience in videolaryngoscopy was associated with a reduced angle deviation compared to inexperienced physicians. As with other studies, GS intubation time (median 24 s) exceeded the time needed for DL (53 s). In 3 patients randomized to DL where intubation by DL failed, intubation was successful following GS use. The authors concluded that “GlideScope videolaryngoscopy reduces movements of the cervical spine in patients with unsecured cervical spines and therefore might reduce the risk of secondary damage during emergency intubation of patients with cervical spine trauma.”


The GS can also be useful in some cases of difficult fibreoptic intubation [86Mannion S, O’Donnell BD. Turning the corner on intubation: fibrescope-assisted videolaryngoscopy. Can J Anaesth 2009; 56(11): 878-9.
[] [PMID: 19655214] ]. Here, the GS is introduced in the usual manner, followed by introduction of the fibreoptic bronchoscope. Such an arrangement provides simultaneous ‘micro’ and ‘macro’ views that can be particularly helpful. In the teaching setting, the instructor is able to use the video laryngoscopy device to see the tip of the bronchoscope as controlled by the student, so the instructor can provide real-time guidance to supplement the view provided by the bronchoscope. When used for purely clinical purposes, the GS can assist in a fiberoptic intubation by providing an alternative view of the airway; such a view can be helpful, for example, in the case of a bloody airway or severely distorted anatomy. Also, should the tracheal tube get caught on the arytenoids or other laryngeal structures, it becomes evident on the GS display, and appropriate corrective action (such as twisting the tube) can easily be taken. Also note that the procedure can be performed either awake or under general anesthesia depending on the clinical circumstances.


The Nerve Integrity Monitoring (NIM) tube is often used for intra-operative recurrent laryngeal nerve monitoring during thyroid and parathyroid surgery [87Sarı S, Erbil Y, Sümer A, et al. Evaluation of recurrent laryngeal nerve monitoring in thyroid surgery. Int J Surg 2010; 8(6): 474-8.
[] [PMID: 20601257] , 88Randolph GW, Dralle H, Abdullah H, et al. Electrophysiologic recurrent laryngeal nerve monitoring during thyroid and parathyroid surgery: international standards guideline statement. Laryngoscope 2011; 121(Suppl. 1): S1-S16.
[] [PMID: 21181860] ]. Positioning of this special tube with its embedded electrodes to the correct depth is critically important [89Lu IC, Chu KS, Tsai CJ, et al. Optimal depth of NIM EMG endotracheal tube for intraoperative neuromonitoring of the recurrent laryngeal nerve during thyroidectomy. World J Surg 2008; 32(9): 1935-9.
[] [PMID: 18392652] ]. This positioning is most easily achieved using the GS, as it allows both the anesthesiologist and the surgical team to witness correct placement of the NIM tube with outstanding clarity [90Berkow L, Dackiw AP, Tufano RP. Use of the GlideScope for placement of a recurrent laryngeal nerve monitoring endotracheal tube. J Clin Anesth 2011; 23(1): 81-3.
[] [PMID: 21296257] -92Nekhendzy V, Lopez JR, Damrose EJ. A method of securing the Xomed endotracheal tube for accurate monitoring of the recurrent laryngeal nerve. J Clin Anesth 2012; 24(3): 259-60.
[] [PMID: 22495085] ].


In addition to facilitating orotracheal intubation, the GS can be useful for the placement of nasotracheal tubes [93Hirabayashi Y. GlideScope videolaryngoscope facilitates nasotracheal intubation. Can J Anaesth 2006; 53(11): 1163-4.
[] -99Lili X, Zhiyong H, Jianjun S. A comparison of the GlideScope with the Macintosh laryngoscope for nasotracheal intubation in patients with ankylosing spondylitis. J Neurosurg Anesthesiol 2013.
[PMID: 23764717] ]. Unlike that case when DL is used, Magill forceps are not employed; instead, to position the tube into the glottis one uses a combination of rotating the tube, flexion of the patient's neck and /or minimal rotation of the patient's head. Jones et al. [94Jones PM, Armstrong KP, Armstrong PM, et al. A comparison of glidescope videolaryngoscopy to direct laryngoscopy for nasotracheal intubation. Anesth Analg 2008; 107(1): 144-8.
[] [PMID: 18635480] ] offer the following additional tip: once the tube tip of has entered the vocal cords, it is often helpful to reduce the distraction of the anterior neck tissues by lowering the GS, advancing the tube into the trachea, and then lifting the GS back up to ensure the tube is still between the vocal cords.

An important reason that Magill forceps are not employed with GS-assisted placement of nasotracheal tubes is that the design of the forceps is optimized for use with DL. Boedeker has developed a curved forceps design optimized for videolaryngoscopy [100Boedeker BH, Bernhagen MA, Miller DJ, Doyle DJ. Comparison of the Magill forceps and the Boedeker (curved) intubation forceps for removal of a foreign body in a Manikin. J Clin Anesth 2012; 24(1): 25-7.
[] [PMID: 22284314] ]; the curve of these forceps “allows both the tip of the forceps and the glottic opening to be simultaneously visible in the field of view during videolaryngoscopy” making them suitable for both nasotracheal tube positioning as well as for the removal of glottic foreign bodies.

Galgon and Ketzler [101Galgon RE, Ketzler JT. The GlideScope for videolaryngoscopy-assisted nasotracheal-to-orotracheal tube exchange in the intensive care unit in a patient with a known difficult airway. J Clin Anesth 2012; 24(5): 412-4.
[] [PMID: 22658369] ] have described how the GS might be used to assist in the conversion from a nasotracheal tube to an orotracheal tube in a patient with a known difficult airway. The technique used was described as follows:

The GlideScope videolaryngoscope was inserted, achieving a full view of the glottic inlet with the nasotracheal tube in situ. An endotracheal tube (ETT) loaded on a GlideRite Rigid Stylet was advanced through the oropharynx into view. Advancement of this ETT to the glottic opening was tested and achieved. With both tracheal tubes in view, the nasotracheal tube cuff was deflated and withdrawn from the glottic opening. While maintaining videoscopic visualization, the orotracheal tube was advanced through the vocal cords into the trachea.

A similar approach can be used to assist in the conversion from an orotracheal tube to a nasotracheal tube [102Liu HP, Xue FS, Guo XL, Liao X. Orotracheal to nasotracheal intubation exchange in pediatric patients with a difficult airway. Paediatr Anaesth 2010; 20(4): 377-9.
[] [PMID: 20470351] -104Xue FS, Zhang YM, Yuan YJ, Liu JH, Liao X. Orotracheal to nasotracheal tube exchange in children. Minerva Anestesiol 2010; 76(4): 302-3.
[PMID: 20332746] ].


The GS has proven to be useful in a number of cases where Double-Lumen Tube (DLT) placement was expected or proved to be difficult by DL [105El-Tahan MR. Videolaryngoscopes for placement of double lumen tubes: Is it time to say goodbye to direct view? Saudi J Anaesth 2016; 10(2): 218-27.
[] [PMID: 27051377] ]. A case report by Hernandez and Wong [106Hernandez AA, Wong DH. Using a Glidescope for intubation with a double lumen endotracheal tube. Can J Anaesth 2005; 52(6): 658-9.
[] [PMID: 15983163] ] offers some suggestions for left DLT placement using the GS:

We suggest bending the stylet of the DLT so that the distal 16 to 20 cm of the DLT curve follows the curve of the Glidescope, and the other end of the DLT angles out to the right side. After the bronchial cuff passes through the VC, withdraw the stylet of the DLT about 2 cm. Then, rotate the DLT 90° counterclock-wise while advancing the DLT to the desired depth.

Other reports on the use of the GS with DLTs have been provided by other authors [107Chen A, Lai HY, Lin PC, Chen TY, Shyr MH. GlideScope-assisted double-lumen endobronchial tube placement in a patient with an unanticipated difficult airway. J Cardiothorac Vasc Anesth 2008; 22(1): 170-2.
[] [PMID: 18249357] -109Onrubia X, Lluch-Oltra A, Armero R, Baldo J. Use of GlideScope for double lumen endotracheal tube insertion in an awake patient with difficult airway. Rev Esp Anestesiol Reanim 2013.
[PMID: 23849718] ]. Onrubia et al. [109Onrubia X, Lluch-Oltra A, Armero R, Baldo J. Use of GlideScope for double lumen endotracheal tube insertion in an awake patient with difficult airway. Rev Esp Anestesiol Reanim 2013.
[PMID: 23849718] ] describe a case of GlideScope-assisted awake DLT insertion under topical anesthesia in a patient known to be difficult to intubate. Bussieres et al. [110Bussières JS, Martel F, Somma J, Morin S, Gagné N. A customized stylet for GlideScope® insertion of double lumen tubes. Can J Anaesth 2012; 59(4): 424-5.
[] [PMID:

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